Effects of Herbal Antioxidants on Oxidative Stress and Reproduction
DOI:
https://doi.org/10.64614/vzs-6Keywords:
Oxidative stress, plant antioxidants, reactive oxygen, reactive nitrogenAbstract
Oxidative stress is an undesirable condition that is tolerated up to a certain level in cell metabolism and life, but generally causes many negative factors. When these toxic metabolites cannot be neutralized by antioxidants, they trigger the formation of many diseases and can be described as the starting components for an unhealthy life. Human health is directly related to the food consumed. For this reason, today there is an increasing desire to return to nature and the natural in order to improve the quality of life and healthy living. Natural plants that have survived from our ancestors to the present day are becoming the center of attention. In order to obtain a natural animal product without chemical residue, reproductive physiology must first continue without disruption. The purpose of this review is to eliminate the negative effects of oxidative stress on reproductive systems and all systems with natural Antioxidant plants. The aim of this study is to scan the existing data on the effects and use of antioxidant plants in order to provide the natural animal products that humanity longs for, which are healthy, have a unique taste, smell and aroma, and do not contain any chemical residue.
References
Adetunji, A.O., Price, J., Owusu, H., Adewale, E.F., Adesina, P.A., Saliu, T.P., Zhu, Z., Xedzro, Z., Asiamah, E. & Islam, S. (2025). Mechanisms by which phytogenic extracts enhance livestock reproductive health: current insights and future directions. Frontiers in Veterinary Science, 12, 1568577.
Agarwal, A., Gupta, S., & Sharma, R.K. (2005). Role of oxidative stress in female reproduction. Reproductive Biology and Endocrinology, 3, 1-21.
Agarwal, A., & Sekhon, L. H. (2010). The role of antioxidant therapy in the treatment of male infertility. Human fertility, 13(4), 217-225.
Agarwal, A., Aponte-Mellado, A., Premkumar, B. J., Shaman, A., & Gupta, S. (2012). The effects of oxidative stress on female reproduction: a review. Reproductive Biology and Endocrinology, 10, 1-31.
Altunay, C., & Taştan, Ö. (2023). Vitex Agnus-Castus: Faydaları, Klinik Çalışmalar ve Gelecekteki Potansiyel Gıda Uygulamaları. Turkish Journal of Agriculture-Food Science and Technology, 11(11), 2185-2193.
Betteridge, D.J. (2000). What is oxidative stress. Metabolism, 49(2), 3-8.
Bhardwaj, J.K., Panchal, H., & Saraf, P. (2021). Ameliorating effects of natural antioxidant compounds on female infertility: A review. Reproductive Sciences, 28(5), 1227-1256.
Birben, E., Sahiner, U.M., Sackesen, C., Erzurum, S., & Kalayci, O. (2012). Oxidative stress and antioxidant defense. World Allergy Organization Journal, 5, 9-19.
Deveci, H.A., Nur, G., Ali Kırpık, M., Harmankaya, A., & Yıldız, Y. (2016). Fenolik bileşik içeren bitkisel antioksidanlar. Kafkas Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 9(1), 26-32.
Embuscado, M.E. (2015). Spices and herbs: Natural sources of antioxidants–a mini review. Journal of Functional Foods, 18, 811-819.
Ghasemi Pirbalouti, A., Siahpoosh, A., Setayesh, M., & Craker, L. (2014). Antioxidant activity, total phenolic and flavonoid contents of some medicinal and aromatic plants used as herbal teas and condiments in Iran. Journal of Medicinal Food, 17(10), 1151-1157.
Gharagozloo, P., & Aitken, R.J. (2011). The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. Human Reproduction, 26(7), 1628-1640.
Gülcin, I. (2012). Antioxidant activity of food constituents: an overview. Archives of Toxicology, 86(3), 345-391.
Jimoh, O.A., Oyeyemi, W.A., Okin-Aminu, H.O., & Oyeyemi, B.F. (2021). Reproductive characteristics, semen quality, seminal oxidative status, steroid hormones, sperm production efficiency of rabbits fed herbal supplements. Theriogenology, 168, 41-49.
Juan, C.A., Pérez de la Lastra, J.M., Plou, F.J., & Pérez-Lebeña, E. (2021). The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. International Journal of Molecular Sciences, 22(9), 4642.
Kumar, M., Kumar, V., Roy, D., Kushwaha, R., & Vaiswani, S. (2014). Application of herbal feed additives in animal nutrition-a review. International Journal of Livestock Research, 4(9), 1-8.
Lawanson, A.A., Akinlade, O.O., & Obi, G.C. (2021). Antıoxıdants In Anımal Productıon And Reproductıon-A Revıew.
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., ... & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 757-772.
Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews, 4(8), 118.
Lushchak, V. I. (2014). Free radicals, reactive oxygen species, oxidative stress and its classification. Chemico-Biological Interactions, 224, 164-175
Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005). Oxidative stress and vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(1), 29-38.
Mirzaei-Aghsaghali, A., Syadati, S. A., & Fathi, H. (2012). Some of thyme (Thymus vulgaris) properties in ruminant's nutrition.
Mohammadi, F., Nikzad, H., Taherian, A., Amini Mahabadi, J., & Salehi, M. (2013). Effects of herbal medicine on male infertility. Anatomical Sciences Journal, 10(4), 3-16.
Murphy, M.P. (2009). How mitochondria produce reactive oxygen species. Biochemical Journal, 417(1), 1-13.
Nguyen-Thanh, T., Dang-Ngoc, P., Bui, M. H., Le-Minh, T., & Nguyen-Vu, Q. H. (2024). Effectiveness of Herbal medicines on male reproductive system: Evidence from meta-analysis. Pharmacological Research-Modern Chinese Medicine, 12, 100462.
Öztürk, B., Konyalıoğlu, S., Kantarcı, G., & Çetinkol, D. (2005). İzmir yöresindeki yabani Lavandula stoechas L. Subsp. stoechas taksonundan elde edilen uçucu yağın bileşimi, antibakteriyel, antifungal ve antioksidan kapasitesi. Anadolu Ege Tarımsal Araştırma Enstitüsü Dergisi, 15(1), 61-72.
Önenç, S.S., & Açıkgöz, Z. (2005). Aromatik bitkilerin hayvansal ürünlerde antioksidan etkileri. Hayvansal Üretim, 46(1).
Pandey, A.K., Kumar, P., & Saxena, M.J. (2019). Feed additives in animal health. Nutraceuticals in Veterinary Medicine, 345-362.
Pham-Huy, L.A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. International journal of biomedical science: IJBS, 4(2), 89.
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., ... & Bitto, A. (2017). Oxidative stress: harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 2017(1), 8416763.
Pisoschi, A.M., & Pop, A. (2015). The role of antioxidants in the chemistry of oxidative stress: A review. European Journal of Medicinal chemistry, 97, 55-74
Prasad, S., Patel, B., Kumar, P., Mitra, P., & Lall, R. (2025). Cranberry: A promising natural product for animal health and performance. Current Issues in Molecular Biology, 47(2), 80.
Radwan Nadia, L., Hassan, R.A., Qota, E.M., & Fayek, H.M. (2008). Effect of natural antioxidant on oxidative stability of eggs and productive and reproductive performance of laying hens. International Journal of Poultry Science, 7(2), 134-150.
Rani, V., Deep, G., Singh, R. K., Palle, K., & Yadav, U.C. (2016). Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sciences, 148, 183-193.
Reuter, S., Gupta, S.C., Chaturvedi, M.M., & Aggarwal, B.B. (2010). Oxidative stress, inflammation, and cancer: how are they linked? Free Radical Biology and Medicine, 49(11), 1603-1616.
Schieber, M., & Chandel, N.S. (2014). ROS function in redox signaling and oxidative stress. Current Biology, 24(10), R453-R462.
Showell, M.G., Mackenzie-Proctor, R., Brown, J., & Yazdani, A. (2014). Antioxidants for male subfertility. Cochrane Database of Systematic Reviews, (12), Cd007411.
Sies, H., Berndt, C., & Jones, D.P. (2017). Oxidative stress. Annual Review of Biochemistry, 86(1), 715-748.
Surai, P.F. (2016). Antioxidant systems in poultry biology: superoxide dismutase. Journal of Animal Research and Nutrition, 1(1), 8.
Tremellen, K. (2008). Oxidative stress and male infertility—a clinical perspective. Human Reproduction Update, 14(3), 243-258.
Turner, T.T., & Lysiak, J.J. (2008). Oxidative stress: a common factor in testicular dysfunction. Journal of Andrology, 29(5), 488-498.
Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology, 39(1), 44-84.
Wang, Y., Branicky, R., Noë, A., & Hekimi, S. (2018). Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling. Journal of Cell Biology, 217(6), 1915-1928.
Yılmaz, S. (2019). Karabaş otu (Lavandula stoechas) yağının sazan balığı (Cyprinus carpio) yemlerine ilavesinin büyüme performansı ve bazı kan parametreleri üzerine etkileri. COMU Journal of Agriculture Faculty, 7(1), 187-193
Yıldız, S., Yavaş, H., Gürbüz, O., & Değirmencioğlu, N. (2015). Türkiye’de yetişen yaban mersini meyvesinin fenolik bileşiklerinin karakterizasyonu. Gıda ve Yem Bilimi Teknolojisi Dergisi, (15).
Young, I.S., & Woodside, J.V. (2001). Antioxidants in health and disease. Journal of Clinical Pathology, 54(3), 176-186.
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